Surgical management for squamous cell carcinoma of vulva
Identifieur interne : 000A77 ( Main/Exploration ); précédent : 000A76; suivant : 000A78Surgical management for squamous cell carcinoma of vulva
Auteurs : Ayi Kossigan Amavi [Maroc] ; Laurent Kouadio [Maroc] ; Komlan Adabra [Maroc] ; Kodjo Tengue [Maroc] ; Fouad Tijami [Togo] ; Abdelouahed Jalil [Togo]Source :
- The Pan African Medical Journal [ 1937-8688 ] ; 2016.
Abstract
To analyze our surgical management and the result of squamous cell carcinoma (SCC) of vulva. Retrospectively, we collected 38 cases of SCC; 17 cases of them were early SCC and 21 cases were locally advanced. The patients underwent primary surgery. The survival was estimated using Kaplan-Meier analysis and the log rank test. The mean age was 60.78 years. Total vulvectomy was performed in all patients. Superficial and deep incision of bilateral inguinal lymphadenectomy was performed by separates incisions for SCC infiltrating more than 1mm. The average tumor size was 53 mm (10 to 140mm). Morbidity was 42.1%. Lateral resection margin ≥8mm was obtained in 57.1%. Eighteen patients benefited from adjuvant radiotherapy. The follow-up median was 19.4 months (6 to 61.5 month) with 05 recurrences in 12 months. The survival using the Kaplan-Meyer analysis at 5 years, was 62.1% (71.2%N- vs 46.7%N+; p = 0.13). We identified two groups for locally advanced vulva cancer. Primary surgery keeps its place. Neo adjuvant radio chemotherapy followed by surgery is the alternative treatment for locally extensive lesions.
Url:
DOI: 10.11604/pamj.2016.24.145.8485
PubMed: 27642483
PubMed Central: 5012828
Affiliations:
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Chirurgie Oncologique, Institut National d'Oncologie, Rabat, Maroc</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Service de Chirurgie Oncologique, Institut National d'Oncologie, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Kouadio, Laurent" sort="Kouadio, Laurent" uniqKey="Kouadio L" first="Laurent" last="Kouadio">Laurent Kouadio</name><affiliation wicri:level="3"><nlm:aff id="AF0001">Service de Chirurgie Oncologique, Institut National d'Oncologie, Rabat, Maroc</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Service de Chirurgie Oncologique, Institut National d'Oncologie, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Adabra, Komlan" sort="Adabra, Komlan" uniqKey="Adabra K" first="Komlan" last="Adabra">Komlan Adabra</name><affiliation wicri:level="3"><nlm:aff id="AF0001">Service de Chirurgie Oncologique, Institut National d'Oncologie, Rabat, Maroc</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Service de Chirurgie Oncologique, Institut National d'Oncologie, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Tengue, Kodjo" sort="Tengue, Kodjo" uniqKey="Tengue K" first="Kodjo" last="Tengue">Kodjo Tengue</name><affiliation wicri:level="3"><nlm:aff id="AF0001">Service de Chirurgie Oncologique, Institut National d'Oncologie, Rabat, Maroc</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Service de Chirurgie Oncologique, Institut National d'Oncologie, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Tijami, Fouad" sort="Tijami, Fouad" uniqKey="Tijami F" first="Fouad" last="Tijami">Fouad Tijami</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Chirurgie Générale, Viscérale, Chirurgie Oncologique, Clinique Médico-chirurgicale, Centre Hospitalier Universitaire Sylvanus Olympio, Lomé, Togo</nlm:aff><country xml:lang="fr">Togo</country><wicri:regionArea>Chirurgie Générale, Viscérale, Chirurgie Oncologique, Clinique Médico-chirurgicale, Centre Hospitalier Universitaire Sylvanus Olympio, Lomé</wicri:regionArea><wicri:noRegion>Lomé</wicri:noRegion></affiliation></author><author><name sortKey="Jalil, Abdelouahed" sort="Jalil, Abdelouahed" uniqKey="Jalil A" first="Abdelouahed" last="Jalil">Abdelouahed Jalil</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Chirurgie Générale, Viscérale, Chirurgie Oncologique, Clinique Médico-chirurgicale, Centre Hospitalier Universitaire Sylvanus Olympio, Lomé, Togo</nlm:aff><country xml:lang="fr">Togo</country><wicri:regionArea>Chirurgie Générale, Viscérale, Chirurgie Oncologique, Clinique Médico-chirurgicale, Centre Hospitalier Universitaire Sylvanus Olympio, Lomé</wicri:regionArea><wicri:noRegion>Lomé</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Pan African Medical Journal</title><idno type="eISSN">1937-8688</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To analyze our surgical management and the result of squamous cell carcinoma (SCC) of vulva. Retrospectively, we collected 38 cases of SCC; 17 cases of them were early SCC and 21 cases were locally advanced. The patients underwent primary surgery. The survival was estimated using Kaplan-Meier analysis and the log rank test. The mean age was 60.78 years. Total vulvectomy was performed in all patients. Superficial and deep incision of bilateral inguinal lymphadenectomy was performed by separates incisions for SCC infiltrating more than 1mm. The average tumor size was 53 mm (10 to 140mm). Morbidity was 42.1%. Lateral resection margin ≥8mm was obtained in 57.1%. Eighteen patients benefited from adjuvant radiotherapy. The follow-up median was 19.4 months (6 to 61.5 month) with 05 recurrences in 12 months. The survival using the Kaplan-Meyer analysis at 5 years, was 62.1% (71.2%N<sup>-</sup> vs 46.7%N<sup>+</sup>; p = 0.13). We identified two groups for locally advanced vulva cancer. Primary surgery keeps its place. Neo adjuvant radio chemotherapy followed by surgery is the alternative treatment for locally extensive lesions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hacker, Nf" uniqKey="Hacker N">NF Hacker</name></author><author><name sortKey="Berek, Js" uniqKey="Berek J">JS Berek</name></author><author><name sortKey="Hacker, Nf" uniqKey="Hacker N">NF Hacker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berliere, M" uniqKey="Berliere M">M Berlière</name></author><author><name sortKey="Coibion, M" uniqKey="Coibion M">M Coibion</name></author><author><name sortKey="Kridelka, F" uniqKey="Kridelka F">F Kridelka</name></author><author><name sortKey="Marechal, M" uniqKey="Marechal M">M Maréchal</name></author><author><name sortKey="Simon, P" uniqKey="Simon P">P Simon</name></author><author><name sortKey="Squifflet, Jl" uniqKey="Squifflet J">JL Squifflet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benedet, Jl" uniqKey="Benedet J">JL Benedet</name></author><author><name sortKey="Bender, H" uniqKey="Bender H">H Bender</name></author><author><name sortKey="Jones, H" uniqKey="Jones H">H Jones</name></author><author><name sortKey="Ngan, Hys" uniqKey="Ngan H">HYS Ngan</name></author><author><name sortKey="Pecorelli, S" uniqKey="Pecorelli S">S Pecorelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jk" uniqKey="Chan J">JK Chan</name></author><author><name sortKey="Sugiyama, V" uniqKey="Sugiyama V">V Sugiyama</name></author><author><name sortKey="Pham, H" uniqKey="Pham H">H Pham</name></author><author><name sortKey="Gu, M" uniqKey="Gu M">M Gu</name></author><author><name sortKey="Rutgers, J" uniqKey="Rutgers J">J Rutgers</name></author><author><name sortKey="Osann, K" uniqKey="Osann K">K 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sortKey="Tillmanns, T" uniqKey="Tillmanns T">T Tillmanns</name></author><author><name sortKey="Scribner, D" uniqKey="Scribner D">D Scribner</name></author><author><name sortKey="Gold, M" uniqKey="Gold M">M Gold</name></author><author><name sortKey="Walker, J" uniqKey="Walker J">J Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, Nf" uniqKey="Hacker N">NF Hacker</name></author><author><name sortKey="Van Der Velden, J" uniqKey="Van Der Velden J">J Van der Velden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palaia, I" uniqKey="Palaia I">I Palaia</name></author><author><name sortKey="Bellati, F" uniqKey="Bellati F">F Bellati</name></author><author><name sortKey="Calcagno, M" uniqKey="Calcagno M">M Calcagno</name></author><author><name sortKey="Musella, A" uniqKey="Musella A">A Musella</name></author><author><name sortKey="Perniola, G" uniqKey="Perniola G">G Perniola</name></author><author><name 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Hernandez</name></author><author><name sortKey="Webb, Mj" uniqKey="Webb M">MJ Webb</name></author><author><name sortKey="Cliby, Wa" uniqKey="Cliby W">WA Cliby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaudineau, A" uniqKey="Gaudineau A">A Gaudineau</name></author><author><name sortKey="Weitbruch, D" uniqKey="Weitbruch D">D Weitbruch</name></author><author><name sortKey="Quetin, P" uniqKey="Quetin P">P Quetin</name></author><author><name sortKey="Heymann, S" uniqKey="Heymann S">S Heymann</name></author><author><name sortKey="Petit, T" uniqKey="Petit T">T Petit</name></author><author><name sortKey="Volkmar, P" uniqKey="Volkmar P">P Volkmar</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Maroc</li><li>Togo</li></country><region><li>Rabat-Salé-Kénitra</li></region><settlement><li>Rabat</li></settlement></list><tree><country name="Maroc"><region name="Rabat-Salé-Kénitra"><name sortKey="Amavi, Ayi Kossigan" sort="Amavi, Ayi Kossigan" uniqKey="Amavi A" first="Ayi Kossigan" last="Amavi">Ayi Kossigan Amavi</name></region><name sortKey="Adabra, Komlan" sort="Adabra, Komlan" uniqKey="Adabra K" first="Komlan" last="Adabra">Komlan Adabra</name><name sortKey="Kouadio, Laurent" sort="Kouadio, Laurent" uniqKey="Kouadio L" first="Laurent" last="Kouadio">Laurent Kouadio</name><name sortKey="Tengue, Kodjo" sort="Tengue, Kodjo" uniqKey="Tengue K" first="Kodjo" last="Tengue">Kodjo Tengue</name></country><country name="Togo"><noRegion><name sortKey="Tijami, Fouad" sort="Tijami, Fouad" uniqKey="Tijami F" first="Fouad" last="Tijami">Fouad Tijami</name></noRegion><name sortKey="Jalil, Abdelouahed" sort="Jalil, Abdelouahed" uniqKey="Jalil A" first="Abdelouahed" last="Jalil">Abdelouahed Jalil</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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